PIPERAZINE SYRUP
PIPERAZINE SYRUP Piperazine has activity against A. lumbricoides and E. vermicularis. In many parts of the world, it has been replaced by less toxic agents such as mebendazole. However, because of its lower cost, piperazine is still frequently used. Piperazine blocks the helminth muscle response to acetylcholine by altering membrane ion permeability and causing hyperpolarization and decreased action potentials. Flaccid paralysis ensues and the worms…